Scientific Research Papers
Ready for a science deep dive? Here are selected research papers on the study of prions (aka misfolded proteins or prion particles) and how they affect brain diseases.
“Change the world through science.”
– Claudio Soto, CSO & CoFounder
Detection of Misfolded Ab Oligomers for Sensitive Biochemical Diagnosis of Alzheimer’s Disease
Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid
De novo induction of amyloid-b deposition in vivo
Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo
Prion-like features of misfolded Aβ and tau aggregates
Titration of biologically active amyloid–b seeds in a transgenic mouse model of Alzheimer’s disease
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
Prion-like characteristics of the bacterial protein Microcin E492
Diagnosing prion diseases- needs, challenges and hopes
Amyloids, prions and the inherent infectious nature of misfolded protein aggregates
Protein Misfolding and Neurodegeneration
Generation of prions in vitro and the protein-only hypothesis
Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission
In Vivo Spreading of Tau Pathology
Prion hypothesis: the end of the controversy?
Transmissible Proteins: Expanding the Prion Heresy
Protein Misfolding in Neurodegenerative Diseases: The Key Pending Questions
Amyloid-beta and tau pathology following repetitive mild traumatic brain injury
Type 2 diabetes as a protein misfolding disease
Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies
Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies
Do good by doing well, do well by doing good.”
– Russ Lebovitz, CEO & CoFounder
Discovering the Cure
We believe Prions are the bad actors that drive many yet incurable diseases. Cracking the code on Prions is the key in finding successful drugs, making the incurables curable.
Alzheimer’s and Parkinson’s are our top priorities.