Scientific Research Papers

Ready for a science deep dive? Here are selected research papers on the study of prions (aka misfolded proteins or prion particles) and how they affect brain diseases.

“Change the world through science.”

– Claudio Soto, CSO & CoFounder

Detection of Misfolded Ab Oligomers for Sensitive Biochemical Diagnosis of Alzheimer’s Disease

Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid

De novo induction of amyloid-b deposition in vivo

Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo

Prion-like features of misfolded Aβ and tau aggregates

Titration of biologically active amyloid–b seeds in a transgenic mouse model of Alzheimer’s disease

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism

Prion-like characteristics of the bacterial protein Microcin E492

Diagnosing prion diseases- needs, challenges and hopes

Amyloids, prions and the inherent infectious nature of misfolded protein aggregates

Protein Misfolding and Neurodegeneration

Generation of prions in vitro and the protein-only hypothesis

Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission

In Vivo Spreading of Tau Pathology

Prion hypothesis: the end of the controversy?

Transmissible Proteins: Expanding the Prion Heresy

Protein Misfolding in Neurodegenerative Diseases: The Key Pending Questions

Amyloid-beta and tau pathology following repetitive mild traumatic brain injury

Type 2 diabetes as a protein misfolding disease

Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

Do good by doing well, do well by doing good.”

– Russ Lebovitz, CEO & CoFounder

Discovering the Cure

We believe Prions are the bad actors that drive many yet incurable diseases. Cracking the code on Prions is the key in finding successful drugs, making the incurables curable.

Alzheimer’s and Parkinson’s are our top priorities.

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