Scientific Research Papers

Here are selected research papers on the study of misfolded proteins (or prion particles) and how they affect brain diseases.

“Change the world through science.”

– Claudio Soto, CSO & CoFounder

Detection of Misfolded Ab Oligomers for Sensitive Biochemical Diagnosis of Alzheimer’s Disease

Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid

De novo induction of amyloid-b deposition in vivo

Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo

Prion-like features of misfolded Aβ and tau aggregates

Titration of biologically active amyloid–b seeds in a transgenic mouse model of Alzheimer’s disease

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism

Prion-like characteristics of the bacterial protein Microcin E492

Diagnosing prion diseases- needs, challenges and hopes

Amyloids, prions and the inherent infectious nature of misfolded protein aggregates

Protein Misfolding and Neurodegeneration

Generation of prions in vitro and the protein-only hypothesis

Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission

In Vivo Spreading of Tau Pathology

Prion hypothesis: the end of the controversy?

Transmissible Proteins: Expanding the Prion Heresy

Protein Misfolding in Neurodegenerative Diseases: The Key Pending Questions

Amyloid-beta and tau pathology following repetitive mild traumatic brain injury

Type 2 diabetes as a protein misfolding disease

Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

Do good by doing well, do well by doing good.”

– Russ Lebovitz, CEO & CoFounder

Scroll to Top