How It Works

Our Prion Detection Science℠ (PDS) mimics and amplifies the misfolding proteins’ domino effect in Alzheimer’s and Parkinson’s patients’ brains.

Six-Step Process

Our PDS technology platform, named Seeded Aggregation Assays or SAA, accelerates the process in which normal proteins misfold and spread into a zombie protein army, a 20- to 50-year cycle in the brain to 100-hours in the laboratory. 

Here’s a simple 6-step process for our test:

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We’re People-Focus

You are our priority. You are the reason we work hard to solve age-old problems. It takes a village with you in the center, surrounded by families, doctors, and caretakers. In communities, we thrive.

We’re Science-Forward

We’re people of a breakthrough-mindset. Our mission is to cure the incurables through science. We strive to change the world one molecule at a time.

We Protect Your Privacy

We’re committed to protecting your personal information and medical data. Confidentiality and privacy are of the utmost importance to us. Anonymity is our middle name.

Why Should You Trust Amprion?

We are proud to receive the FDA’s Breakthrough Device Designation award for detecting Misfolded Synuclein, associated with Parkinson’s Disease, as well as several types of dementia.

Amprion’s scientists pioneer the research on misfolded proteins and have published a vast library of articles on this subject. We’re also proud to call the NIH, Michael J Fox Foundation, and Alzheimer’s Drug Discovery Fund, among our most supportive research partners.

Learn more about how our Prion Detection Science works below.

Brain Science 101

Our body is made up of cells, which consist of different types of molecules. Of all molecule types, proteins are highly critical. They serve diverse functional and structural roles.

Encoded directly by our genes (DNA), proteins work by folding into particular, stable three-dimensional shapes. This structural integrity is a vital indication of a healthy normal protein.

Under the circumstances related to genetics, environment, general health, and brain aging, some proteins begin to misfold, shifting the normal structure into a non-functional or toxic form. A small number of misfolded proteins can self-replicate by converting other normal proteins to misfold.

What Are Prion Proteins?

When the misfolded proteins self-replicate, we call them prions or prion-proteins, prion-like particles, or misfolded protein aggregates.

Prion proteins have an alarming ability to replicate autonomously and recruit other normal proteins to misfold, multiplying exponentially. These misfolded proteins lead to progressively worsening symptoms over time.

These zombie proteins damage the brain during the incubation period without showing signs of memory loss or executive disabilities. Neurodegenerative diseases cause permanent, irreversible damages to the brain because the brain has a minimal capacity to repair damaged neurons. 

Prion proteins operate in stealth, with incubation periods as long as several decades. A single misfolded protein can replicate overtime to fill the brain with its progeny and trigger massive neuronal loss.

Prions Are Proteins Gone Rogue.

In movie-speak, prion-proteins spread like a zombie protein army, taking on a life of their own.

Learn more about how prions damage brain health. 

Cause of Neurodegenerative Diseases

When prion-proteins reach a critical mass in the brain, they trigger neurons’ destruction and cause neurodegenerative disorders. As a result, the body shows neurological symptoms, including memory loss and/or other higher brain disorders.

As the brain suffers neurological damage, it affects our cognitive abilities, motor skills, and other critical functions.

Through natural progression, the conditions worsen to full-blown neurodegenerative diseases, affecting our daily lives. How we think, speak, act, move are compromised. Our memories are blurred. 

In short, we become a different person to loved ones. The patient is trapped within.

What Are Common Neurodegenerative Diseases

Some of the common prion-related neurodegenerative diseases include:

  • Alzheimer’s,
  • Parkinson’s,
  • Lewy Body Dementia,
  • Frontotemporal Dementia,
  • ALS, and
  • Creutzfeldt-Jakob disease, to name a few.

At Amprion, we view prion-related diseases as conditions on the same spectrum, referred to as ParkinZheimer. 

ParkinZheimer Key Biomarkers

Decades of research have identified three prion-proteins as key biomarkers for common neurodegenerative diseases, including Alzheimer’s and Parkinson’s, and Lewy Body Dementia:

Learn about how misfolded proteins work here.

parkinson's research and care center

ParkinZheimer Key Biomarkers

Decades of research have identified three prion-proteins as key biomarkers for common neurodegenerative diseases, including Alzheimer’s and Parkinson’s, and Lewy Body Dementia:

Learn about how misfolded proteins work here.

Our Prion Biomarker Testing

Amprion anticipates the commercial rollout of a variety of Prion Biomarker Tests for the diagnosis of ParkinZheimer diseases.

Our first biomarker test SYNTap-CSF helps doctors diagnose certain motor and cognitive diseases decades before the body shows any symptoms. Find out how SYNTap-CSF can accurately diagnose such diseases as Parkinson’s and LBD using cerebral spinal fluid (CSF).

Our biomarker testing enables personalized treatments that target specific prions to increase treatment efficacy. This laser focus on biomarkers helps patients, doctors, and drug companies select the right clinical trials to speed drug development.

Our upcoming service – the Prion Biomarker Panel (PBP) – will offer you and your doctor an in-depth analysis of which prion proteins are involved. With early detection and on-going monitoring, you and your doctor can make informed choices, both lifestyle and medicinal, to achieve optimum brain health.

Learn more about the key benefits of prion biomarker tests.

Why Use Cerebral Spinal Fluid (CSF) vs. Blood Test?

In the early stages of neurodegenerative disease, prion-proteins are localized mostly in brain cells. Therefore, CSF has the highest concentration of misfolded proteins, making it the most reliable sample with the highest accuracy.

When the prion proteins are readily detectable in the blood, the disease is in the late stage as the prions have breached the blood-brain barrier and spread throughout the body via the blood.

CSF vs. Blood

Why Use Cerebral Spinal Fluid (CSF) vs. Blood Test?

In the early stages of neurodegenerative disease, prion-proteins are localized mostly in brain cells. Therefore, CSF has the highest concentration of misfolded proteins, making it the most reliable sample with the highest accuracy.

When the prion proteins are readily detectable in the blood, the disease is in the late stage as the prions have breached the blood-brain barrier and spread throughout the body via the blood.

You treat a disease; you win, you lose. You treat a person, I guarantee you, you’ll win, no matter what the outcome.
Robin Williams
Robin Williams