How It Works

Our Prion Detection Science℠ (PDS) mimics and amplifies the misfolding proteins’ domino effect in the brains of patients suffering from neurological diseases, including Alzheimer’s, Lewy Body Dementia (LBD), and Parkinson’s.

Six-Step Process

Our PDS technology platform, named Seeded Aggregation Assays (or SAA), accelerates the process of normal proteins misfolding and spreading into a zombie protein army, a 20- to 50-year cycle in the brain to 100-hours in the laboratory. 

Here’s the 6-step process for our test:

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We’re People-Focused

YOU are the reason we work hard to solve age-old problems. You are the center of our work. In communities, we thrive.

We’re Science-Forward

We’re people of a breakthrough-mindset. Our mission is to cure the incurables through science. We strive to change the world one molecule at a time.

We Protect Your Privacy

We’re committed to protecting your personal information and medical data. Confidentiality and privacy are of the utmost importance to us. Anonymity is our middle name.

Why Should You Trust Amprion?

We are proud to receive the FDA’s Breakthrough Device Designation award for detecting Misfolded Synuclein, associated with LBD, Parkinson’s Disease, and other types of dementia.

Amprion’s scientists pioneer the research on misfolded proteins and have published a vast library of peer review articles in many prestigious scientific journals.

We’re also proud to call the NIH, Alzheimer’s Drug Discovery Fund, and the Michael J Fox Foundation among our most supportive research partners.

Brain Science 101

Our body is made up of cells, which consist of different types of molecules. Of all molecule types, proteins are highly critical. They serve diverse functional and structural roles.

Encoded directly by our genes (DNA), proteins work by folding into particular, stable three-dimensional shapes. This structural integrity is a vital indication of a healthy normal protein.

Under the circumstances related to genetics, environment, general health, and brain aging, some proteins begin to misfold, shifting the normal structure into a non-functional or toxic form. These misfolded proteins are also known as Prions or Prion Proteins. 

A small number of misfolded proteins can self-replicate by converting other normal proteins to misfold.

Characteristics of Prion Proteins?

Prion proteins have an alarming ability to replicate autonomously and recruit other normal proteins to misfold, multiplying exponentially. These misfolded proteins lead to progressively worsening symptoms over time.

These zombie proteins damage the brain during the incubation period without showing signs of memory loss or executive disabilities. Neurodegenerative diseases cause permanent, irreversible damages to the brain because the brain has a minimal capacity to repair damaged neurons. 

Prion proteins operate in stealth, with incubation periods as long as several decades. A single misfolded protein can replicate over time to fill the brain with its progeny and trigger massive neuronal loss.

Proteins Gone Rogue

In movie-speak, prion-proteins spread like a zombie protein army, taking on a life of their own.

Learn more about how prions damage brain health. 

Cause of Neurodegenerative Diseases

When prion-proteins reach a critical mass in the brain, they trigger neurons’ destruction and cause neurodegenerative disorders. As a result, the body shows neurological symptoms, including memory loss and/or other higher brain disorders.

As the brain suffers neurological damage, it affects our cognitive abilities, motor skills, and other critical functions.

Through natural progression, the conditions worsen to full-blown neurodegenerative diseases, affecting our daily lives. How we think, speak, act, move are compromised. Our memories are blurred. 

In short, we become a different person to loved ones. The patient is trapped within.

What Are Common Neurodegenerative Diseases

Some of the common prion-related neurodegenerative diseases include:

  • Alzheimer’s,
  • Parkinson’s,
  • Lewy Body Dementia,
  • Frontotemporal Dementia,
  • ALS, and
  • Creutzfeldt-Jakob disease, to name a few.

At Amprion, we consider all brain diseases exist on a spectrum called ParkinZheimer

ParkinZheimer Key Biomarkers

Decades of research have identified three prion-proteins as key biomarkers for common neurodegenerative diseases, including Alzheimer’s, LBD Parkinson’s.

parkinson's research and care center

ParkinZheimer Key Biomarkers

Decades of research have identified three prion-proteins as key biomarkers for common neurodegenerative diseases, including Alzheimer’s and Parkinson’s, and Lewy Body Dementia:

Our Prion Biomarker Testing

Amprion anticipates the commercial rollout of a variety of Prion Biomarker Tests for the diagnosis of ParkinZheimer diseases.

Our first biomarker test, SYNTaphelps doctors diagnose certain motor and cognitive diseases decades before the body shows any symptoms. Find out how this test can accurately diagnose such diseases as Parkinson’s and LBD, using cerebralal spinal fluid (CSF).

Our biomarker testing enables personalized treatments that target specific prions to increase treatment efficacy. This laser focus on biomarkers helps doctors and drug companies to better match the right clinical trials with the right patients.

Our upcoming service – the Prion Biomarker Dashboard – will offer your doctor an in-depth analysis of the prions involved. With early detection and ongoing monitoring, you and your doctor can make informed choices, both lifestyle and medicinal, to achieve optimum brain health.

Learn more about the key benefits of prion biomarker tests.

Distinct Benefit of CSF Testing

In the early stages (before patients show symptoms), prion-proteins are localized mostly in the brain, making CSF the most reliable sample for accurate testing.

CSF vs. Blood

Distinct Benefit of CSF Testing

In the early stages (before patients show symptoms), prion-proteins are localized mostly in the brain, making CSF the most reliable sample for accurate testing.

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Muhammad Ali
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